The 7 Best Mattress Cleaners of 2023

Best Overall

Bissell 1400B Little Green Multi-Purpose Portable Carpet and Upholstery Cleaner

4.6

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To really deep clean your mattress, it’s best to rely on both a cleaning solution and physical cleaning. We think the Bissell Little Green cleaner is easy to use and very portable. All you need to do is fill the cleaning solution tank with the best formula for your needs. Bissell makes refills that work with the unit, but other enzyme-based cleaners or professional strength for heavy smells and stains will work, too.

The cleaner is powered up to target specific areas. The cleaning is applied directly to the stain, then vacuumed up. Dirty solution, including the particles that cause the stain, collects right in the water reservoir. When you’re done, simply empty the reservoir and store the cleaner alongside your vacuum or mop. It has a carrying handle on the top to make moving it around easy.

Because you’ll need to purchase a cleaning solution for this unit, the bill can certainly add up. Fortunately, it lasts for years and can be used on any stain or mess. That means less wear on your carpets and upholstery as well as your mattress. Bissell also donates money to pets in need with every purchase, so you can feel good about your purchase, too!

Price at time of publish: $124

_{Type: Machine | Dimensions: 8.25 x 17.25 x 12.5 inches | Weight: 9.65 pounds | Capacity: 48 ounces | Time Needed: N/A | Do Not Use On: Not listed}

Best Budget

Resolve Multi-Fabric Cleaner and Upholstery Stain Remover

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Not only is this stain remover and cleaner very budget-friendly, but it can also work on a variety of surfaces around your home, making it extra functional and efficient. It’s safe for surfaces that can be cleaned with water-based cleaners and wet solvents. These are noted on most surfaces or listed by the manufacturer as W or Ws on the tag. This cleaner is ideal for mattresses, most carpets, upholstery, and other common surfaces. It can lift up food, wine, juice, and urine.

You should only use this formula on the stain for 5 minutes. Let it sit, then blot it up. Resist the urge to rub the surface back and forth because that might actually force the stain further into the fibers. Instead, blot with a clean, dry cloth or old rag.

Price at time of publish: $5

_{Type: Spray | Dimensions: 2.75 x 4.55 x 10.38 inches | Weight: 1.7 pounds | Capacity: 22 ounces | Time Needed: 5 minutes | Do Not Use On: Velvet, silk, vinyl, leather}

Best Spray

Hate Stains Co. Miss Mouth’s Messy Eater Stain Treater

4.5

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This pocket-sized spray is made specifically for parents of babies, but it works for any household that has to deal with stains and cleaning. It uses a gentle formula that is still super effective on stains. The formula works on food, grass and dirt, and urine stains as well. You can actually see the stains lessen after just a few seconds. After letting it sit, you can blot up any extra to get rid of stains completely.

The spray bottle is quite small, which makes it portable. This also means that it gets used up quickly. It comes in a set of two but is still pricey. It is safe for all surfaces as well as pets and children. The Miss Mouth’s Messy Eater Spray is great for homes that want one product that they can use on all surfaces without worry.

Price at time of publish: $15

_{Type: Spray | Dimensions: 1.5 x 3 x 6.25 inches | Weight: 9 ounces | Capacity: 9 ounces | Time Needed: Not listed | Do Not Use On: Not listed}

Best Stain Remover

Kleanlogik Mattress Stain Remover Spray

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We love that this spot treatment is made specifically for mattresses and is effective on grass, wine, oil, and blood. It lifts up stains to make your mattress look as good as new. It’s most effective and fast on newer stains, but it’ll also work on older, dried up stains, tool. Plus, it’ll take care of those mishaps on white and colorfast fibers without damaging the look or color.

It’s a small capacity and meant to be a spot treatment rather than a larger cleaning regimen. To use, just spray on the stain. It starts working right away to lift up the mess. Just make sure the stain is fully covered, which might mean using up quite a bit of the cleaning solution on individual spots and stains. Don’t rub back and forth to clean out the stain. Instead, just dab until the cleaning solution (and the stain) are gone.

Price at time of publish: $10

_{Type: Spray | Dimensions: 10.35 x 2.91 x 2.13 inches | Weight: 8 ounces | Capacity: 8 ounces | Time Needed: Not listed | Do Not Use On: Not listed}

Best Enzyme

Angry Orange Odor Eliminator & Pet Stain Remover

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This solution works for stains and odors by using an enzyme formula to dissolve the molecules that actually cause odors. How does it work? These enzymes help lift proteins, tannins, and oil stains from fabrics. It’s especially effective on pet stains and odors, such as ammonia. Expect Angry Orange to have a mild citrus scent that masks the unpleasant smells it removes. It also comes in a fresh scent.

You should make sure to let the area dry completely before letting pets or small children around it. The formula is not safe, especially if you think they might accidentally ingest the solution. The scent is meant to last for a few hours at least. If you prefer something unscented, you may want to try a different enzyme-based cleaner.

Price at time of publish: $30

_{Type: Spray | Dimensions: 4 x 2 x 9 inches | Weight: 32 ounces | Capacity: 32 ounces | Time Needed: Immediate | Do Not Use On: Not listed}

Best for Pet Odor

Rocco & Roxie Supply Co. Professional Strength Stain & Odor Eliminator

4.5

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Having a pet that has accidents on your mattress is the not-so-fun part of owning your cute doggie, but the Rocco & Roxie spray cleaner is the best option to take care of both stains and odors. It uses enzymes to break down the stain and lift it up. This spray is also safe to use on carpet and upholstery, as well as safe for pets and people. The best aspect is that it removes smelly odor for good, reducing the likelihood that your pet will have an accident in the same place.

You’ll need to let it sit on the surface for 5 to 10 minutes for the best results. Older stains and messes may take more time. It works by breaking down the ammonia crystals. More crystals to break down means more time or more solution. You won’t need a ton, but larger stains will take a bit more care.

Price at time of publish: $20

_{Type: Spray | Dimensions: 5 x 2 x 10 inches | Weight: 2 pounds | Capacity: 2 pounds | Time Needed: 5-10 minutes | Do Not Use On: Not listed}