Keppra (Levetiracetam) in Dogs and Cats

Treating Canine and Feline Seizures With Keppra (Levetiracetam)

Dog And Cat
Dog and Cat. Getty - Stone / GK Hart/Vikki Hart

Keppra (levetiracetam) is a newer medication that can be used for treating seizures in dogs and cats. Seizures and epilepsy are commonly diagnosed conditions in the dog and can occur in the cat as well. Medications traditionally used to treat seizures and epilepsy include phenobarbital and potassium bromide.

However, in some pets, these medications alone may not always adequately control seizures. In addition, some animals are not able to tolerate phenobarbital or potassium bromide well or the pet owner may simply wish to avoid the potential side effects associated with them.

In these instances, an alternative anticonvulsant medication may be necessary and Keppra (levetiracetam) may be a good choice.

Keppra (Levetiracetam) for Seizures in Dogs and Cats

Keppra can be used by itself as an anticonvulsant medication. It can also be used in conjunction with phenobarbital and/or potassium bromide. Less of those other medications may be needed when using Keppra, which can reduce the side effects they may cause.

Keppra is available in different dosages, including 500-milligram and 750-milligram extended-release tablets. It does need to be dosed more frequently than other anticonvulsant medications. In many cases, the medication must be given three times daily or the extended-release tablets given twice a day. This is because it is rapidly broken down in the body, with an elimination half-life between four and six hours. It also has a wide margin of safety, so overdoses are less likely.

It doesn't require monitoring of blood levels.

Levetiracetam appears to be relatively safe for both dogs and cats but studies are still ongoing to investigate any adverse effects it may have. It does not appear to affect the liver or liver enzymes (measured in the blood) as phenobarbital and potassium bromide can.

 It is not broken down by the liver but instead passes into the urine. This is why it is safer for pets who may have impaired liver function, including those whose seizures are due to liver damage from other medications such as phenobarbital.

Potential Side Effects of Levetiracetam in Dogs and Cats

Most dogs and cats seem to tolerate levetiracetam quite well. In dogs, side effects which may be seen are drowsiness, changes in behavior, and gastrointestinal symptoms such as vomiting or diarrhea. In cats, a decrease in appetite can occur.

Extended-release tablets (such as levetiracetam 500 mg) must be given intact, not split or crushed, or too much of the medication will be released at once. If your pet is likely to chew them, it is better to use the regular formulation rather than the extended-release formulation.

It is important to remember that levetiracetam has been used to date only in a limited number of pets and less is known about the effects in cats than in dogs.

As with any other anticonvulsant medication, levetiracetam should never be stopped suddenly. Doing so may place your pet at risk of life-threatening seizure activity.


Plumb DC. Plumb's Veterinary Drug Handbook, 8th edition.

Wiley. 2015.

Podell, M., Volk, H.A., Berendt, M., Löscher, W., Muñana, K., Patterson, E.E. and Platt, S.R. (2016), 2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs. J Vet Intern Med, 30: 477–490. doi:10.1111/jvim.13841 

Please note: This article has been provided for informational purposes only. If your pet is showing any signs of illness, please consult a veterinarian as quickly as possible.